But while celebrating her latest career success, it appears the 39-year-old actress's love life may not be quite as smooth.
Despite appearing inseparable in recent weeks after reuniting in November, the couple spent the Christmas holidays apart, prompting speculation their relationship may have soured.
On the rocks: Jennifer Aniston and John Mayer looking affectionate in New York on December 18thAfter spending a week in New York promoting her new film Marley & Me and spending time with Mayer, Aniston returned to LA ahead of Christmas on December 20th, leaving her lover back in the Big Apple.
Mayer spent Christmas with his family before returning to the West Coast with his brothers Carl and Ben on Boxing Day.
The New York Post claimed Aniston utilised her relationship with Mayer - putting on uncharacteristically public displays of affection - to promote her movie.
The Post's Page Six column wrote: ' Jennifer Aniston is celebrating her box-office pummeling of ex-hubby Brad Pitt - but she's doing it without her boy toy by her side.
'Aniston toted Mayer around through all her promotional gigs to deter interviewers from focusing on her single status.'
It is unclear whether the couple, who only started dating again last month after a four month relationship earlier this year, will be spending New Year's Eve together.
After spending Christmas Eve dining with best friend Courteney Cox, husband David Arquette and their daughter Coco, Aniston's movie opened on Christmas Day, receiving record takings.
Box office winner: Aniston and her Marley & Me co-star Owen Wilson
Third place: Brad Pitt was trounced in the box office by his former wife with his film The Curious Case Of Benjamin ButtonMarley & Me, also starring Owen Wilson, took $14.6million (£10million) on its opening day and took an additional $37million (£25.3million) over the weekend.
Meanwhile, her ex-husband Pitt's new film The Curious Case Of Benjamin Button took $11.4million (£7.8million) on the opening day, landing at the number three spot.
Earlier this month, Aniston spoke publicly about her feelings for Mayer, describing his as 'extraordinary'.
Jennifer, 39, and John, 31, resumed their relationship in November - three months after the singer announced he had dumped the actress following their brief four month romance.
The singer was left looking ungentlemanly when he claimed he dumped Jennifer during a video interview in August.
He said: 'Have me as a man who ended a relationship stand here and write some truth...
'There's no lying, there's no cheating. There's no nothing. People are different, they have different chemistry, they have different lives.
'I ended a relationship because there is no lying. I ended a relationship to be alone because I don't want to waste somebody's time if something's not right. I don't waste people's time.'